Optimal Structure of Particles-Based Superparamagnetic Microrobots

@article{mellal2015,
  author = {Mellal, Lyès and Belharet, Karim and Folio, David and
    Ferreira, Antoine},
  publisher = {Springer Science and Business Media LLC},
  title = {Optimal {Structure} of {Particles-Based} {Superparamagnetic}
    {Microrobots}},
  journal = {Journal of Nanoparticle Research},
  volume = {17},
  number = {64},
  pages = {265-274},
  date = {2015-01-30},
  url = {https://dfolio.fr/publications/articles/2015mellalJNR.html},
  doi = {10.1007/s11051-014-2733-3},
  issn = {1572-896X},
  langid = {en},
  abstract = {This paper presents an optimal design strategy for
    therapeutic magnetic micro carriers (TMMC) guided in real time by a
    magnetic resonance imaging (MRI) system. As aggregates of TMMC must
    be formed to carry the most amount of drug and magnetic actuation
    capability, different clustering agglomerations could be arranged.
    Nevertheless, its difficult to predict the hydrodynamic behavior of
    any arbitrary-shaped object due to the nonlinear hydrodynamic
    effects. Indeed, the drag effect is related not only to the
    properties of the bolus but also to its interaction with the fluid
    viscosity, the free-stream velocity and the container geometry. In
    this work, we propose a mathematical framework to optimize the TMMC
    aggregates to improve the steering efficiency in experimental
    endovascular conditions. The proposed analysis is carried out on
    various sizes and geometries of microcarrier: spherical,
    ellipsoid-like and chain-like of microsphere structures. We analyze
    the magnetophoretic behavior of such designs to exhibit the optimal
    configuration. Based on the optimal design of the boluses,
    experimental investigations were carried out in mm-sized fluidic
    artery phantoms to demonstrate the steerability of the magnetic
    bolus using a proof-of-concept setup. The experiments demonstrate
    the steerability of the magnetic bolus under different velocity,
    shear-stress and trajectory constraints with a laminar viscous
    fluidic environment. Preliminary experiments with a MRI system
    confirms the feasibility of the steering of these TMMCs in hepatic
    artery microchannel phantom.}
}