This paper presents an optimal design strategy for therapeutic magnetic micro carriers (TMMC) guided in real time by a magnetic resonance imaging (MRI) system. As aggregates of TMMC must be formed to carry the most amount of drug and magnetic actuation capability, different clustering agglomerations could be arranged. Nevertheless, its difficult to predict the hydrodynamic behavior of any arbitrary-shaped object due to the nonlinear hydrodynamic effects. Indeed, the drag effect is related not only to the properties of the bolus but also to its interaction with the fluid viscosity, the free-stream velocity and the container geometry. In this work, we propose a mathematical framework to optimize the TMMC aggregates to improve the steering efficiency in experimental endovascular conditions. The proposed analysis is carried out on various sizes and geometries of microcarrier: spherical, ellipsoid-like and chain-like of microsphere structures. We analyze the magnetophoretic behavior of such designs to exhibit the optimal configuration. Based on the optimal design of the boluses, experimental investigations were carried out in mm-sized fluidic artery phantoms to demonstrate the steerability of the magnetic bolus using a proof-of-concept setup. The experiments demonstrate the steerability of the magnetic bolus under different velocity, shear-stress and trajectory constraints with a laminar viscous fluidic environment. Preliminary experiments with a MRI system confirms the feasibility of the steering of these TMMCs in hepatic artery microchannel phantom.
Keywords: Targeted drug delivery, Magnetic steering, Superparamagnetic microrobot, Optimal design
@article{mellal2015,
author = {Mellal, Lyès and Belharet, Karim and Folio, David and
Ferreira, Antoine},
publisher = {Springer Science and Business Media LLC},
title = {Optimal {Structure} of {Particles-Based} {Superparamagnetic}
{Microrobots}},
journal = {Journal of Nanoparticle Research},
volume = {17},
number = {64},
pages = {265-274},
date = {2015-01-30},
url = {https://dfolio.fr/publications/articles/2015mellalJNR.html},
doi = {10.1007/s11051-014-2733-3},
issn = {1572-896X},
langid = {en},
abstract = {This paper presents an optimal design strategy for
therapeutic magnetic micro carriers (TMMC) guided in real time by a
magnetic resonance imaging (MRI) system. As aggregates of TMMC must
be formed to carry the most amount of drug and magnetic actuation
capability, different clustering agglomerations could be arranged.
Nevertheless, its difficult to predict the hydrodynamic behavior of
any arbitrary-shaped object due to the nonlinear hydrodynamic
effects. Indeed, the drag effect is related not only to the
properties of the bolus but also to its interaction with the fluid
viscosity, the free-stream velocity and the container geometry. In
this work, we propose a mathematical framework to optimize the TMMC
aggregates to improve the steering efficiency in experimental
endovascular conditions. The proposed analysis is carried out on
various sizes and geometries of microcarrier: spherical,
ellipsoid-like and chain-like of microsphere structures. We analyze
the magnetophoretic behavior of such designs to exhibit the optimal
configuration. Based on the optimal design of the boluses,
experimental investigations were carried out in mm-sized fluidic
artery phantoms to demonstrate the steerability of the magnetic
bolus using a proof-of-concept setup. The experiments demonstrate
the steerability of the magnetic bolus under different velocity,
shear-stress and trajectory constraints with a laminar viscous
fluidic environment. Preliminary experiments with a MRI system
confirms the feasibility of the steering of these TMMCs in hepatic
artery microchannel phantom.}
}
For attribution, please cite this work as:
Mellal L., Belharet K., Folio D., and Ferreira
A., “Optimal Structure of Particles-Based Superparamagnetic
Microrobots,”J. Nanoparticle Res.., vol. 17, pp.
265–274, January 2015. [Online]. Available: https://dfolio.fr/publications/articles/2015mellalJNR.html