Modeling and Characterization of Deformable Soft Magnetic Microrobot for Targeted Therapy

Lyès Mellal; David Folio; Antoine Ferreira

doi:10.1109/LRA.2021.3107102

Abstract

Magnetic nanoparticles (MNPs) are very attractive components in many biomedical applications, particularly as therapeutic magnetic microcarriers (TMMC). Although MNPs can be effectively gathered and transported using external magnetic fields, the optimal delivery is yet to be fully investigated. In this letter, we discuss the modeling and the characterization of deformable soft magnetic microrobots under various magnetic field conditions. The microrobots considered consist of superparamagnetic iron oxide (SPIO) immersed in different carrier fluids, and the behavior of which has been characterized experimentally under weak magnetic fields. The experimental results clearly show that the observations properly follow the model prediction.

Media

The supplementary files is available on the publisher site

Funding

This work was supported by the French National Institute of Health and Medical Research (Inserm) “Plan Cancer” 2014–2019 program, Project: Microrobots Targeting Glioblastoma.

Reuse

CC BY 4.0

Copyright

© 2021 IEEE. Personal use of this material is permitted. Permission from IEEE must be obtained for all other uses, in any current or future media, including reprinting/republishing this material for advertising or promotional purposes, creating new collective works, for resale or redistribution to servers or lists, or reuse of any copyrighted component of this work in other works.

Citation

BibTeX citation:

@article{mellal2021,
  author = {Mellal, Lyès and Folio, David and Ferreira, Antoine},
  publisher = {IEEE},
  title = {Modeling and {Characterization} of {Deformable} {Soft}
    {Magnetic} {Microrobot} for {Targeted} {Therapy}},
  journal = {IEEE Robotics and Automation Letters},
  volume = {6},
  number = {3},
  pages = {8293-8300},
  date = {2021-10-01},
  url = {https://ieeexplore.ieee.org/document/9521741},
  doi = {10.1109/LRA.2021.3107102},
  langid = {en-US},
  abstract = {Magnetic nanoparticles (MNPs) are very attractive
    components in many biomedical applications, particularly as
    therapeutic magnetic microcarriers (TMMC). Although MNPs can be
    effectively gathered and transported using external magnetic fields,
    the optimal delivery is yet to be fully investigated. In this
    letter, we discuss the modeling and the characterization of
    deformable soft magnetic microrobots under various magnetic field
    conditions. The microrobots considered consist of superparamagnetic
    iron oxide (SPIO) immersed in different carrier fluids, and the
    behavior of which has been characterized experimentally under weak
    magnetic fields. The experimental results clearly show that the
    observations properly follow the model prediction.}
}

For attribution, please cite this work as:

Mellal L., Folio D., and Ferreira A., “Modeling and Characterization of Deformable Soft Magnetic Microrobot for Targeted Therapy,” Robot. Autom. Lett., vol. 6, pp. 8293–8300, October 2021. [Online]. Available: https://ieeexplore.ieee.org/document/9521741